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CWP can be associated with reduced lung function, ... assess whether a greater commitment of resources is required given the expansion in industry and re-emergence of some mining-related lung diseases in recent years. CONCLUSION. CWP in its most severe form can lead to chronic respiratory failure and premature death. A high cumulative exposure ...
Background Amyotrophic lateral sclerosis (ALS) associated with TAR DNA-binding protein 43 (TDP-43) aggregation has been considered as a lethal and progressive motor neuron disease. Recent studies have shown that both C-terminal TDP-43 (C-TDP-43) aggregates and oligomers were neurotoxic and pathologic agents in ALS and frontotemporal …
Alzheimer disease is diagnosed postmortem by the density and spatial distribution of β-amyloid plaques and tau-bearing neurofibrillary tangles.The major protein component of each lesion adopts cross-β-sheet conformation capable of binding small molecules with submicromolar affinity. In many cases, however, Alzheimer pathology overlaps with Lewy body disease, …
The linking between targets/diseases and herbs/ingredients is determined by the overlap between disease-associated targets and the potential protein targets of the herbs/ingredients. With the aid of AI text mining, we linked 15 179 targets and 32 529 diseases to 9191 herbs and 61 966 ingredients in TCMBank.
neurodegenerative disorders, including Parkinson's disease (PD), and Alzheimer 's disease (AD) (1). In PD, alpha-synuclein (α-syn) is incorporated into intracellular inclusions, referred to as Lewy bodies and Lewy neurites, whereas in AD, intracellular neurofibril-lary tangles of tau protein, and extracellular amyloid-β (Aβ)
Although the mining workforce has declined during these years, reported cases of disease and illness from 1985 through 2001 are above the levels reported in 1983 and 1984. An average of …
Alzheimer disease is diagnosed postmortem by the density and spatial distribution of beta-amyloid plaques and tau-bearing neurofibrillary tangles. The major protein component of each lesion adopts cross-beta-sheet conformation capable of binding small molecules with submicromolar affinity. ... Differentiating Alzheimer disease-associated ...
Over the years, the impact of mining on the economy, environment, and society has attracted several views (Balasubramanian, 2017; Festin et al., 2018; Mensah et al., 2015; Ocansey, 2013).A study, (Widana, 2019) conceptualized the impacts of mining into several forms such as functionality (socio-economic, political and environment), duration (short-term, …
The accumulation of tau aggregates is associated with neurodegenerative diseases collectively known as tauopathies. Tau aggregates isolated from different tauopathies such as Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy have distinct cryo-electron microscopy structures with respect to their packed fibril cores.
a, Map of 396 identified river mineral mining areas.More than 80% (334/396) of mining areas are within 20° of the Equator. b–e, Planet Labs satellite images of mining sites identified in a ...
Identification of disease-associated genes is a crucial step in unraveling the underlying molecular mechanisms of complex diseases. As a potent computational tool for recognizing potential associations between genes and diseases, heterogeneous graphs allow for more comprehensive and accurate modeling and analysis of intricate molecular interactions within …
Industrial mining projects can play an important role in global sustainable development if associated health risks are minimised and opportunities maximised. While a broad body of evidence from quantitative …
a The NDD-associated Httex1 protein forms aggregates in cells within 48 h. When the protein is unlabeled, these aggregates have a core and shell ultrastructure. Labeled Httex1 (e.g., with GFP ...
This is followed by disease of cellular proliferation, which almost exclusively covers cancer–gene associations. By contrast, we find quite a few associations (7443) for disease of infectious agent, which come exclusively from text mining. The latter is to be expected, since the DISEASES database aims to identify causal associations between ...
Specifically, the model was trained using all known drug–disease associations in the F dataset, and a descending order ranking was performed after obtaining the probabilities of all drug–disease associations. In this process, the top 10 drug candidates associated with Parkinson's disease were selected for in-depth investigation.
Here, we performed an integrative single-cell analysis of OL-lineage cells across a wide range of AD and MS models. We found three disease-associated OLs (DAOs) in mouse models: a DA1 state, associated with elevated expression of inflammatory genes; a DA2 state, associated with elevated expression of genes that influence OL survival; and an interferon …
The aggregation of specific proteins is a histopathological hallmark in various neurodegenerative diseases (NDs), among which Alpha-synuclein (α-Syn) and tau have received increased attention. The targeted protein degradation (TPD) strategy has been studied in the treatment of NDs, but multitarget bifunctional molecules have been ignored. Herein, a series of …
The aggregation of specific proteins is a histopathological hallmark in various neurodegenerative diseases (NDs), among which Alpha-synuclein (α-Syn) and tau have received increased attention. ... in the treatment of NDs, but multitarget b … Discovery of Effective Dual PROTAC Degraders for Neurodegenerative Disease-Associated Aggregates J ...
concerning health effects associated with coal mining: 1. Exposure to coal mine dust causes various pulmonary diseases, including coal workers' pneumoconiosis (CWP) and chronic obstructive pulmonary disease (COPD). 2. Coal miners are also exposed to crystalline silica dust, which causes silicosis, COPD, and other diseases. 3.
Background: The association between mining occupation categories and obstructive lung disease (OLD) has not been well explored in the United States. Methods: National Health Interview Survey (NHIS) data from 2006 to 2015 was used to determine the relationship between mining occupations and diagnosis of chronic bronchitis, emphysema, chronic obstructive …
Soil aggregation plays a critical role in the maintenance of soil structure and crop productivity. Fertilization influences soil aggregation, especially by regulating soil organic carbon (SOC) and total nitrogen (TN) contents in aggregate fractions. Here, we conducted a fixed-site field experiment to quantify the effect of five N application rates: 0, 75, 150, 225, and 300 …
Water-level fluctuation (WLF) can destroy soil aggregates and induce soil organic carbon (SOC) loss, potentially triggering impacts on the concentration of atmospheric carbon dioxide. However, responses of soil aggregate content and aggregate-associated organic carbon to WLF have not been well studied, especially in the water-level fluctuation zone …
Coal is an important global commodity and will remain so for the foreseeable future. Thus, mining of coal will also remain important. Despite improvements in exposure assessment and …
Coal mining remains a sizable industry, with millions of working and retired coal miners worldwide. This article provides an update on recent advances in the understanding of respiratory health issues in coal miners and focuses on the spectrum of disease caused by inhalation of coal mine dust, termed coal mine dust lung disease.
Introduction. Alzheimer disease (AD) is the most common cause of dementia in the elderly population (Hebert et al., 2003).It is defined and definitively diagnosed by the appearance of extracellular β-amyloid (Aβ) plaques and intracellular neurofibrillary lesions in the brain (Hyman, 1997).Because AD progresses hierarchically, the density and spatial distribution of lesions …
The main objective of this study is to review the environmental and hydrological issues associated with mining processes according to the stages in the lifecycle of a mine, the mineral type, and the different mining facilities, as well as the characteristics of the contaminants, by mainly focusing on the coal and aggregate minerals mining and ...
Accumulation of misfolded protein aggregates is a hallmark event in many age-related protein misfolding disorders, including some of the most prevalent and insidious neurodegenerative diseases. Misfolded protein aggregates produce progressive cell damage, organ dysfunction, and clinical changes, which are common also in natural aging.
The accumulation of tau fibrils is associated with neurodegenerative diseases, which are collectively termed tauopathies. Cryo-EM studies have shown that the packed fibril core of tau adopts distinct structures in different tauopathies, such as Alzheimer's disease, corticobasal degeneration, and progressive supranuclear palsy.
Most environmental impacts associated with aggregate mining are benign. Extracting aggregate seldom produces acidic mine drainage or other toxic affects commonly associated with mining of metallic or energy resources. Other environmental health hazards are rare. Most of the impacts that are likely to occur are short-lived, easy to predict and ...
